Scientific Research for Skin-Beauty

Skin-Beauty

Skin-Beauty is a natural and effective formulation for healthy skin appearance and optimal skin tone. The presence of potent mushrooms combined with other essential supplements preserves skin integrity, prevents skin cells damage, and enhances younger skin appearance. Moreover, it positively modulates the expression of an anti-aging component, SIRT1, which increases skin cells survival, reduces skin damage, and delays skin aging. Thus, optimal consumption of Skin-Beauty by FUNGAC essentials Inc. protects skin against oxidative damage and ultraviolet rays that keep the skin vibrant, healthy, and younger. It is important to know that experts processed the highly potent supplements in a well-certified facility following GMP guidelines. This miracle skin product by FUNGAC Essentials Inc. is effective for both men and women. Additionally, the final formulation is packed with Black Pepper Extract for maximum absorption and protection in the gastrointestinal tract.

Features of SKIN-BEAUTY by FUNGAC Essentials Inc.

USDA Certified Organic Ingredients
No Risk of Adverse Events
Non-GMO and Gluten Free
Free from Synthetic Chemicals
Improve Skin Appearance
Promote Skin Health and Wellness
Prevent Skin Damage
Delay Skin Aging
Effective for both Men and Women
Quality Supplements at Cheap Price

Skin Benefits of SKIN-BEAUTY by FUNGAC Essentials Inc.

Promote Skin Health

The Skin-Beauty composition provides potent antioxidant properties that protect skin from harmful toxins, chemicals, and reactive species. As a result, it significantly preserves optimal skin integrity and growth that promote maximum skin health and wellness.

Prevent Skin Damage

The presence of potent skin-protective supplements in the Skin-Beauty formula helps the skin against harmful ultraviolet rays and supports regeneration of endogenous collagen. That ultimately preserve skin structure, improve skin tone, and increase younger skin appearance.

Delay Skin Aging

Regular consumption of Skin-Beauty by FUNGAC Essentials Inc. delivers an adequate amount of Tremella fuciformis extract that helps regulate the expression of anti-aging Sirtuin Proteins. As a result, it promotes a younger skin appearance, prevents skin damage, and delays skin aging.

Note, please read the Skin-Beauty label for the suggested dose and precautionary measures.

References (Medical Research Studies)

Research Data/Copy paste

Oxidative stress induced by free radicals, which are produced in response to redox reactions, radiation and chemical reactions, can cause DNA and protein damage. Such stress is associated with the development of many diseases, such as atherosclerosis, diabetes mellitus, articular gout, and cancer (1,2). Hydrogen peroxide (H₂O₂) is one of type of reactive oxygen species (ROS) produced in normal cells during cell respiration and metabolism (3). However, many studies have indicated that a high concentration of H₂O₂, present under pathological conditions, may induce various human degenerative diseases and aging. Furthermore, H₂O₂ also interacts with intracellular ions such as iron and copper, leading to a chain reaction that produces more reactive radicals and amplifies the damage, thereby causing DNA and protein damage (4). Therefore, antioxidants are very important for the treatment of oxidative-stress-related diseases and aging.

TFPS pre-treatment significantly increased SIRT1 expression during H₂O₂ treatment of cultured human skin fibroblasts, and the SIRT inhibitor nicotinamide reversed this protective effect. Furthermore, TFPS promoted fibroblast SIRT1 expression and then regulated cell aging and survival via decreased expression of p16, p21, p53 and Capsase-3 and activation of ERK and Akt. Our data provide new insight into the protective mechanisms of TFPS during H₂O₂-induced skin injury and suggest that TFPS functions as a SIRT1 activator and could be used as a new anti-skin aging agent.

Antioxidants in food, including vitamin C, polyphenols, tocopherols and flavonoids, may prevent free-radical-induced cell damage (5). They also may attenuate oxidative-stress-induced inflammatory reactions and apoptosis. Many natural plants and fungi contain antioxidant compounds, such as various phenolic compounds, that can be used as antioxidants to alleviate the damage caused by oxidative stress, inflammation, and energy expenditure (6–9). Polyphenols are natural compounds that can be found in fruits, vegetables, red wine and cereals. Epidemiological studies have found a negative correlation between the risk of chronic human diseases and the consumption of a polyphenol-rich diet (10–14).

Tremella fuciformis Berk, belonging to the order Tremellales and the family Tremellaceae, is an edible mushroom that has been a traditional Chinese medicine for centuries. Recently, many studies have revealed that the soluble extract of the polysaccharide fraction purified from Tremella fuciformis polysaccharide (TFPS) has several pharmacological activities, including anti-oxidant, anti-inflammatory, anti-diabetic, antitumor, and anti-aging effects (10,15). TFPS has also been used clinically for cancer and anti-aging treatments in China (16). However, the protective mechanism of TFPS is not clear.

We demonstrated that pretreatment with TFPS suppressed H₂O₂-induced oxidative stress and apoptosis in skin fibroblasts in a concentration-dependent manner and possessed excellent antioxidative properties. Therefore, our present findings may provide a theoretical basis for TFPS as an alternative herbal food supplement and potential pharmacotherapy for skin injury and aging.

However, given that TFPS contains several polysaccharides and has a variety of pharmacological effects, our study, which focused on oxidative stress inhibition and anti-apoptotic effects, has limitations. Further studies are required to define the potential protective mechanisms of TFPS in H₂O₂-induced skin injury.

In summary, we revealed that TFPS exhibits protective properties against hydrogen peroxide-induced oxidative stress and apoptosis mainly by upregulating SIRT1 and promoting downstream signaling, suggesting that TFPS is a potential therapeutic agent for oxidative stress-related skin diseases and skin aging.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561887/

Tremella polysaccharides exhibits antioxidative stress and anti-inflammatory properties in LPS-treated macrophages by inhibiting the miR-155 and NFκB pathways, suggesting that TFPS may be a potential therapeutic agent for the treatment of inflammation-related diseases.⁷⁰Tremella polysaccharide can regulate the expression of Sirtuin protein in cancer cells and participate in fatty acid oxidation, aging, inflammation and other life processes.⁷¹Tremella polysaccharide protects human skin fibroblasts induced by hydrogen peroxide by up-regulating SIRT1 expression,⁷²also, inhibition of lipopolysaccharide-induced human lung cancer cell apoptosis and autophagy by activating SIRT1 expression.⁵⁷Purification of polysaccharide TAPA1 and its acetylated derivative TAPA1-ac, deacetylated derivative TAPA1-deac, and sulfated fraction TAPA1-s from Tremella fuciformis as samples, using H₂O₂ induced PC₁₂ oxidative damage model to evaluate antioxidant Effect and repair of oxidative damage. It was found that the effect was related to different substituents, and positively related to the content of acetyl groups and the degree of substitution (DS).⁴⁷Furthermore, Tremella polysaccharide has been reported to protect cardiomyocytes from oxidative damage in a mouse model of D-galactose-induced aging.⁷³

Skin protection

Skin health is closely related to skin moisture content. When the skin is dehydrated, the intracellular metabolism is disturbed and the stability of the cell membrane is destroyed, causing the skin to lose its elasticity, wrinkles and even rashes. Tremella polysaccharide can be used as a natural moisturizer to relieve skin dehydration, repair the skin barrier and maintain skin health.⁷⁴

The desorption kinetic simulation method was used to study the moisture content stability and characteristics of Tremella polysaccharides obtained under different drying conditions, and the results showed that the Tremella polysaccharides obtained by each drying method had good moisturising and hygroscopic ability.⁷⁵Tremella polysaccharides can reduce the photo-damage of skin caused by ultraviolet rays. After smearing Tremella polysaccharides, the moisture content and collagen content in the skin of animals exposed to ultraviolet rays are significantly higher than those in the control group. In addition, histopathological studies have shown that oral Tremella polysaccharides can promote the regeneration of endogenous collagen and maintain the I/III collagen ratio to protect the skin structure from damage caused by ultraviolet rays.⁷⁶In the isolated pig skin wound healing model, Tremella polysaccharides are also considered to significantly promote wound healing.⁷⁷Apart from the above, Tremella polysaccharides are extremely cost effective compared to traditional humectants hyaluronic acid. The moisturising effect of products added with 0.05% Tremella polysaccharides is already better than products with 0.02% hyaluronic acid, but the cost is only 14% of the latter.²

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172338/

Grape Seed Extract

Regarding the use of GSSP extracts for the treatment of cancer, cytotoxicity and apoptotic cell death induced by extracts from the skins and seeds of Vitis vinifera L. on A431 skin cancer cells were investigated. Phytochemicals from Vitis vinifera L. can selectively target cancer cells and serve as potential antitumor agents providing better efficacy in killing cancer cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696942/

Animal models of surgical wounds, skin abrasions, burns, lacerations, excisional wounds and open fractures

Initiation of gene expression that reasons for the formation of VEGF

Wound healing involves three steps which include: inflammation, proliferation and remodeling. In inflammation, the inflammatory cells like monocytes and macrophages start depositing at the injury site and this step starts immediately after the injury occurs. Proliferative phase of wound healing includes several steps like angiogenesis, epithelialization, collagen aggregation, and formation of granulation tissue and wound interaction. Angiogenesis is the process where new blood vessels grows from existing vessels and hence is crucial in wound healing process. If the flow of blood is restored to the damaged tissues, it’ll provide oxygen and nutrients which is a basic requirement for the support of function and growth of reparative cell (Johnson and Wilgus 2014).

Angiogenesis process is stimulated by Vascular Endothelial Growth Factor (VEGF; Fig. 1) which is the most effective growth factor involved in the process of healing of wounds. VEGF is a signal glycoprotein produced by the cells, also known as Vascular Permeability Factor. In angiogenesis VEGF stimulates the migration and reproduction of epithelial cell. Johnson and Wilgus 2014 stated that VEGF and angiogenesis are two most important factors for the cutaneous wound repair regulation. GSE contains polyphenyl phenolic bioflavonoids, proanthocyanidins which accelerates the process of wound healing (Soto et al. 2015). Different studies of GSE for the management of wound healing and their benefits where mentioned in Table 1. Proanthocyanidins specifically induces the expression of VEGF in human keratinocytes cells responsible for wound healing (Sen et al. 2002). Some epidemiologic studies demonstrated that the phenolic compound present in GSE decreases the endothelial contraction of vessels, activate nitric oxide synthesis, control platelet aggregation and prevent LDL cholesterol oxidation (Sandoo et al. 2010).

In today’s era people want to live young and attractive. They use as many products to protect their skin from harmful effects of environmental stress, UV radiation etc. The facial skin is more susceptible to UV radiation which results in the photo aging. GSE can be used in various cosmetic products. Cosmetics rich in antioxidant provide protection against harmful UV radiations. Skin aging is a natural process which occurs due to the external and internal factors involving genetic, hormonal and environmental factors. Decrease of collagen and its precursor, inflammation and disordered Melanocytes are some changes occur in photo-aging. GSE rich in Proanthocyanidin reduces the lipid oxidation of cellular structure of the skin and inhibits the production of free radicals (Markus and Morris 2008). There are many products available in market having GSE as a core ingredient. These products include tablet, capsules, lotions, creams etc. A study was carried out in which the anti-aging and redox state regulation effects of GSE and cranberry concentrate (CBC) was investigated. After the study it was concluded that proanthocyanidin rich in GSE and CBC extract have promising role as anti-aging and in redox state regulation (Costa et al. 2015). Phenolic acids, phytosterols, flavonoids, tocopherols, carotenoids, tocopherols and tocotrienols, those are having high antioxidant activity and can maintain the skin health are examples of other active compounds of GSE (Devi and Singh 2017).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054588/

Acerola Cherry

Acerola (Malpighia emarginata DC.) is a fruit that is found throughout Central America and within the northern part of South America. Because acerola has high concentrations of AA in the edible part, it is considered to be one of the best sources of AA [13]. Additionally, acerola contains numerous functional phytochemicals, such as carotenoids and polyphenols [14–16]. Previously, we tested for various polyphenols in acerola and found that cyanidin-3-α-O-rhamnoside, pelargonidin-3-α-O-rhamnoside, quercetin-3-α-O-rhamnoside, kaempferol glycosides, astilbin, and proanthocyanidin are present [14, 15, 17]. In addition to polyphenols, we have reported on the contents of various nutritional components such as glucose, fructose, malic acid and several amino acids in the edible part of acerola [17]. The contents of glucose, fructose, malic acid, total polyphenols and total amino acids in acerola was 15 to 16, 14 to 16, 4 to 5, 1.2 to 1.5, and 1.8 to 2.1 g/kg edible portion, respectively [17]. It has been demonstrated that acerola intake exerts protective effects against DNA damage generated by FeSO₄ [18], inhibits lung tumorigenesis induced by nicotine-derived nitrosamine ketone [19], regulates blood glucose levels and exerts anti-inflammatory effects in obese mice [20, 21]. Similarly, we have demonstrated a beneficial effect of acerola in humans; i.e., the intake of acerola juice (AJ) affects the absorption of AA in plasma and minimizes its excretion via urine in healthy Japanese subjects, which suggests improvement of the bioavailability of AA in humans [22]. In the skin, we have previously reported that the intake of acerola polyphenol extracts prevents UVB-induced skin pigmentation in brownish guinea pigs, which possess moderate numbers of melanocytes and melanosomes in the epidermis [23]. Because acerola contains not only a large amount of AA but also beneficial ingredients as noted above, it is important to elucidate the effect of whole juice intake in UVB-irradiated skin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256894/

The crude polyphenol concentrated extract from acerola (C-AP) was used to examine the skin-lightening effect on brownish guinea pigs which had been subjected to controlled UVB irradiation. The results show that C-AP significantly lightened the UVB-irradiated skin pigmentation. Furthermore, treatment with C-AP reduced the content of melanin in B16 melanoma cells, suggesting that the in vivo skin-lightening effect of C-AP was due to the suppression of melanin biosynthesis in melanocytes. In addition, we found that C-AP could effectively inhibit mushroom tyrosinase activity, the main constituents responsible for this effect being thought to be such anthocyanins as cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R). This result indicates that the skin-lightening effect of C-AP can be partly attributed to the suppression of melanogenesis through the inhibition of tyrosinase activity in melanocytes. An oral ingestion of C-AP may therefore be efficacious for reducing UVB-induced hyper-pigmentation by inhibiting the tyrosinase in melanocytes.

https://pubmed.ncbi.nlm.nih.gov/19060403/

Biotin

There is limited data on biotin supplementation to treat dermatologic conditions, 36 especially in patients with normal biotin levels. In children with atopic dermatitis who 37 were biotin deficient, oral biotin resulted in improvement in xerosis and pruritus (n=4, 5 mg/day).1

https://sci-hub.se/10.1016/j.jaad.2018.02.018

Biotin administration may improve the treatment of hair loss when deficiency is detected on the basis of a careful patient history, clinical examination and the determination of serum biotin levels. The use of biotin is rationale in seborrheic dermatitis as the vitamin intercepts the main metabolic pathways underlying the pathogenesis of the disease. Treatment with biotin could also be useful in comedonal acne characterized by a high rate of seborrhea, and may be helpful for acne treated with topical retinoids, contributing to the control of flaking and irritation.

https://pubmed.ncbi.nlm.nih.gov/31638351/

Mushrooms

Recent studies showed that medicinal mushroom Tricholo malobayense possesses many bioactive compounds responsible for anti-ageing activity. Extracted polysaccharide TLH-3 isolated from the fresh fruiting body of Tricholo malobayense shows anti-ageing capability when measured in d-galactose-induced aged mice model (Ding et al. 2016). The isolated methanol extract of medicinal mushroom, Ganoderma lucidum, (Krupodorova et al. 2015) has two novel anti-aging ergosterols, ganodermasidase A and B; these compounds extend the replicative life span of Saccharomyces cerevisiae by regulating the expression of UTH1 oxidative stress-responsive genes (Weng et al. 2010). Table 5 depicts the list of patents that confirmed anti-aging/menopause and other symptom relief using Ganoderma lucidums pores with many other therapeutic applications (Chung and Tong 2005). Many extracted ingredients from the fruiting body of medicinal mushroom such as polysaccharides, polyphenolic, phenolics, terpenoids, selenium, vitamins, and volatile organic compounds show tremendous antioxidant, anti-ageing, anti-wrinkle, skin whitening, and moisturizing effects (Hyde et al. 2010; Wu et al. 2016). Water-soluble polysaccharide (AAP I-a) isolated from Auricularia auricular prevents oxidative stress in d-galactose-induced aged mice. A paste of polysaccharides is used for the production of antiaging creams or lotions and other skin-related cosmetics in the industry (Zhang et al. 2011). These polysaccharides (AAP I-a) have the ability to delay ageing as they result in the inhibition of the functional enzymes responsible for skin ageing, such as elastase, tyrosinase, hyaluronidase and MMP-1 enzymes. These polysaccharides further help in restoring the skin elasticity and stimulating the expression of collagen synthesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056353/