Scientific Research for Erotic For-Play

Erotic For-Play

Erotic for-play is a unique formulation of potent mushrooms combined with Gac fruit for optimal sexual health and reproductive functions. It significantly modulates sexual hormones and positively supports sexual activity for better enjoyment and excitement. Erotic For-Play is specifically designed to enhance low libido, optimize sexual desire and improve various sexual dysfunctions in both men and women. Moreover, it helps promote the sexual drive, preserve vital physiological functions, and increase satisfaction during sexual intercourse, invigorating sexual wellbeing and longevity. Note that an expert’s team scientifically processed the whole ingredients in a well-certified facility following GMP guidelines for an effective FUNGAC product. Plus, Erotic for-Play does not involve any synthetic chemicals and is free from harmful additives. Additionally, the final formulation is packed with Black Pepper Extract for maximum absorption and protection in the gastrointestinal tract.

Features of Erotic for-Play by FUNGAC Essentials Inc.

  • Non-GMO and Gluten-Free formulation
  • USDA Certified Organic Ingredients
  • Free from Synthetic Chemicals
  • No risk of Side Effects
  • Promote Sexual Wellbeing
  • Improve Libido
  • Enhance Sexual Desire
  • Support Sexual Health
  • Effective for Both Men and Women
  • Quality Formulation at Cheap Price

How does Erotic for-Play by FUNGAC Essentials Inc. Work?

The combo mushrooms formulation protects vital cellular functions, optimize sexual hormones level, promote nitric oxide concentration, restores sexual motivation and increase the number and duration of sexual intercourse sessions. Moreover, the presence of potent mushrooms improves sperm count, motility, and survival that support manhood sexual activity. Additionally, both Black Maca and Horny goat weed increase libido, enhance sexual desire and support more enjoyable sexual experiences in both men and women. Also, regular Erotic for-Play by FUNGAC Essentials Inc. increases oxygen consumption, delays fatigue, improves blood flow to vital organs, and increases energy production that aids both sexual performance and stamina.

Health Benefits of Erotic for-Play

Improve Libido and Sexual Performance

Mushrooms are highly reported in Chinese traditional medicine for low libido, sexual performance, and sexual dysfunctions. Erotic for-Play is a perfect combo of sex driving mushrooms that modulate the level of the hormones, including testosterone and estrogen, in both sexes. It significantly improves low libido, optimizes manhood for maximal performance, helps erectile dysfunction, and revitalizes inner vitality and sexual wellbeing. 

Enhance Sexual Desire

The presence of potent aphrodisiacs mushrooms combined with Gac fruit boosts sexual desire and suppresses the lack of sexual arousal. Erotic for-Play naturally enhances the arousal stage in both men and women for perfect sexual intercourse and satisfaction. Additionally, it supports physical endurance and strength spiking up sexual performance and stamina. 

Promote Sexual Health and Activity

Optimal consumption of Erotic for-Play mushrooms combo supports physiological and psychological behaviors during sexual intercourse sessions that improve sexual health and activity. Moreover, it significantly helps mental stress, relieves mood distractions, boosts sexual interest, and promotes optimal sexual activity. 

Note, please read the Erotic for-Play label for suggested dose and precautionary measures. 

 

 

References (Medical Research Studies)

 

Research Data/Copy Paste

 Lentinus

A three-week diet supplemented with an aqueous extract of shiitake led not only to the restoration of sexual motivation in males with initially decreased libido, but also to an increase in the number of ejaculations 1.5 times, and the total duration of mating 1.8 times (19.4 min).

http://labanimalsjournal.ru/en/2618723x-2018-03-03

Shiitake mushrooms are another food high in the testosterone-boosting ingredient zinc, and are a great source of vitamin D. Failure to meet your vitamin D needs can plummet your libido and mess with your mood, according to Scritchfield. Choline, another ingredient found in shiitake mushrooms, “help activate and enhance the neurotransmitter, acetylcholine (ACH), that triggers the sexual message, in both men and women,” she adds.

 

  1. edodesor “shiitake mushroom” has been used for many years to investigate functional properties and to isolate compounds for pharmaceutical use; this is because of its positive effects on human health (Figure 2). It has been utilized to alleviate the common cold for hundreds of years and some scientific evidence has supported this belief [8]. Finimundy et al. [17] have provided experimental information about the aqueous extracts ofL. edodes as potential sources of antioxidant and anticancer compounds. These extracts significantly decreased cell proliferation on tumor as well. Manzi and Pizzoferrato [50] reported that L. edodes contains high levels of β-glucans in the soluble fraction of dietary fiber. Shiitake produces lentinan and β-glucan that suppress leukemia cell proliferation and have antitumor and hypocholesterolemic activity [5, 74–78]. Lentinan is used in clinic assays as adjuvant in tumor therapy and specifically in radiotherapy and chemotherapy. On the other hand, it has been reported that lentinan enhances host resistance against infections by bacteria, fungi, parasites, and virus; it also promotes nonspecific inflammatory responses, vascular dilation, hemorrhage-inducing factors activation, and generation of helper and cytotoxic T cells [17, 74, 79, 80]. In other studies, L. edodes exhibited capacity to inhibit the growth of mouse sarcoma, probably due to the presence of an unspecified water-soluble polysaccharide [50].

Thiol redox status (GSHtotal-2GSSG/GSSG) and niric oxide (NO) concentration increased after shiitake extract whereas H2O2 and 8-isoprostanes did not change. In conclusion, shiitake mushroom extract had no effect on markers of inflammation following prolonged eccentric exercise but demonstrated an antioxidant activity through the regulation of nitric oxide concentration and thiol redox status.

https://pubmed.ncbi.nlm.nih.gov/23756400/

 

Cordyceps

Guo[99] reported that when C. sinensis supplement was administered to 22 males for 8 weeks, it showed 33% increase in sperm count and 29% decrease in the sperm malformations, and 79% increase in the sperm survival rate. Huang et al.[100] reported that C. sinensis dietary supplement can cause the prevention and improvement of adrenal glands and thymus hormones, and the infertile sperm count improved by 300%. Wan et al.[101] reported that when C. sinensis supplement to 189 both men and women, libido decreased and there was improvement of symptoms and desire by 66%. Dong and Yao[102] reported that C. sinensis supplement caused improvement of libido and desire at 86% in women.

  1. sinensis can enhance libido and sexual performance, and can restore impaired reproductive functions, such as impotency or infertility, in both sexes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791983/

https://sci-hub.se/10.1016/j.jfda.2016.10.020

SEXUAL AND REPRODUCTIVE FUNCTION ENHANCEMENT ACTIVITY

Testosterone is necessary for normal sperm development. It activates genes in Sertoli cells, which promote differentiation of spermatogonia. Cordyceps has traditionally been used for the enhancement of sexual function in human beings. Evidence shows that C. sinensis and C. militaris can improve reproductive activity and restore impaired reproductive function (Table 5.2). The administration of C. sinensis enhanced libido and sexual activity, and restored impaired reproductive function in both sexes in human (Zhu, Halpern, and Jones 1998). Such effects are related to the enhancement of testosterone release in plasma through cAMP (adenosine monophosphate)-protein kinase A signal pathway (Hsu et al. 2003a). Fractions of cultured mycelia of C. sinensis with water- soluble low-molecular-weight proteins and polysaccharides of relatively poor water solubility and protein, but not fractions with water-soluble low-molecular-weight polysaccharides, increased testosterone levels in mice (Hsu et al. 2003b; Huang et al. 2004). A protein in C. sinensis contributed to the observed hypotensive and vasorelaxant properties by improving the production of NO (Chiou et al. 2000); this protein might help the penis trap blood for erection, thereby improving sexual function (Drewes, George, and Khan 2003).

Fatigue is defined as difficulty in initiating or sustaining voluntary activity (Chaudhuri and Behan 2004), and can be classified into mental and physical fatigue (Mizuno et al. 2008). Fatigue is a common symptom in sickness and in health. Chronic fatigue can affect an individual’s performance. In addition, long-term accumulated fatigue can lead to karoshi (a Japanese word meaning death as a result of overwork). In China, cordyceps is used to restore health after various diseases and to hasten recovery from exhaustion because of its adaptogenic (antistress) properties and ability to enhance endurance and strength (Bucci 2000).

Oral administration of C. sinensis mycelia water extract at 150 mg/kg/day for 7 days (Koh et al. 2003b) or ingestion of fruiting bodies of C. militaris at 500 mg/kg/day for 4 weeks (Jung, Kim, and Han 2004) significantly prolonged the swimming time of mice by about 20 and 24 minutes, respectively. This effect was related to the enhancement of immunity. The administration of C. sinensis at 150 mg/kg/day for 8 days inhibited the increase of total cholesterol and the decrease of alkaline phosphatase in rats, as well as significantly reversed the decreased weight of liver, adrenal gland, thymus, and thyroid (Koh et al. 2003b). The involvement of cordyceps in adenosine triphosphate (ATP) production also accounts for a decrease in physical fatigue when it is administered. The oral administration of cultured C. sinensis extract (200 mg/kg/day, p.o.) not only improved hepatic energy metabolism and blood flow in dietary hypoferric anemic mice for 4 weeks (Manabe et al. 2000) but also increased significantly the ATP/inorganic phosphate ratio in the liver of normal mice for 3 weeks (Manabe et al. 1996) or for 7 days (Dai et al. 2001) with no steatosis, necrosis, inflammation, or fibrosis in the liver specimens (Manabe et al. 1996 and 2000). Treatment with natural or cultured cordyceps extracts (1 g/kg/day, p.o.) for 3 days enhanced myocardial ATP generation capacity ex vivo in mice by 29% and 32%, respectively, which might be mediated by the enhancement of mitochondrial electron transport (Siu et al. 2004).

Patients having chronic fatigue syndrome often have depression. Around 30–70% of such patients show the features of major depression (Adler 2004). Supercritical fluid extract (SCCS, 2.5–10 mL/kg, p.o.), other than hot water extract (500–2000 mg/kg, p.o.), of C. sinensis show significant antidepressant-like activity. After 5 days of administration, SCCS shortened immobility times in the mouse-tail suspension test, although it had no effect on locomotor activity in the mouse open field test. It was considered that SCCS played an antidepressant-like role by affecting the adrenergic and dopaminergic systems other than the serotonergic system (Nishizawa et al. 2007). In addition, cordyceps has a powerful antioxidant effect, which may eliminate the ROS produced in working muscles during exercise and help in relieving fatigue (Mizuno et al. 2008). Finally, C. sinensis induced a more efficient utilization and consumption of O2, which resulted in a greater survival rate under a hypoxic environment (Lou, Liao, and Lu 1986) in mice. The results indicate a more efficient use of O2 by cordyceps to support essential physiological activities of tissues and improve tolerance to hypoxia-induced acidosis. However, few clinical trials have been conducted on the antifatigue effect of cordyceps, and most of the conducted tests were methodologically flawed, especially in the inclusion of other drugs in the experiments. For instance, capsules containing Cs-4, Rhodiaola rosea, and other ingredients did not enhance muscle-tissue oxygen saturation (Colson et al. 2005) and cycling performance (Earnest et al. 2004) in healthy men. Similarly, ingestion of a supplement containing cultured C. sinensis, adenylpyrophosphoric acid, calcium pyruvate, and yohimbine hydrochloride once 1 hour before a sport activity showed no ergogenic effects in healthy men (Herda et al. 2008). One reason may be that the ingestion schema of C. sinensis was insufficient to elicit positive changes in humans. A 1-week loading phase followed by at least a 2–4-week maintenance phase may be needed to obtain the effect of promoting aerobic capacity and resistance to fatigue. Another reason may be that as these experiments were performed on healthy persons, there were fewer margins for physiological, health, and performance improvement than in diseased or elderly persons (Colson et al. 2005).

https://www.ncbi.nlm.nih.gov/books/NBK92758/

 

Described as a natural exercise mimetic (Kumar et al., 2011), cordyceps is thought to improve performance by increasing blood flow, enhancing oxygen utilization, and acting as an antioxidant (Ko & Leung, 2007; Zhu, et al., 1998a, 1998b). Related to these benefits, a majority of the effects of cordyceps sinensis supplementation have been seen in aerobic performance, showing improvements in maximal oxygen consumption (VO2max) and ventilatory threshold (VT) (Chen et al., 2010; Nicodemus, Hagan, Zhu, & Baker, 2001; Yi, Xi-zhen, & Jia-shi, 2004). Indirectly, there may also be potential effects of cordyceps supplementation on high intensity performance. Enhanced oxygen utilization and blood flow, especially to the liver and non-exercising skeletal muscle, may enhance lactate clearance. This may allow athletes to maintain a higher intensity of exercise, while the reduction of oxidative stress from high intensity exercise may delay fatigue (Adams & Welch, 1980; Brooks, 1985; Mizuno et al., 2008; Rowell et al., 1966). When combined with three weeks of high intensity interval training, a pre-workout blend containing cordyceps sinensis had positive effects on critical velocity, an aerobic performance measure (Smith, Fukuda, Kendall, & Stout, 2010). Despite potential benefits, a number of studies have found no benefits of cordyceps supplementation on aerobic and anaerobic performance (Colson et al., 2005; Earnest et al., 2004; Parcell, Smith, Schulthies, Myrer, & Fellingham, 2004). To date, research on the ergogenic effects of cordyceps is limited and inconclusive as to its benefits to exercise.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/

Aphrodisiac activity

Recently aphrodisiac activity has been reported due to suspected testosterone like metabolites and libido-promoting activity in CS. Wang et al. reported that CS contains a factor that stimulates corticosteroid production in the animal model. In the study, a water-soluble extract of CS was used to investigate its pharmacological function on primary rat adrenal cell cultures and the signaling pathway involved. But authors are not sure about the mechanism of CS induced steriodogenesis, whether it acts directly on the adrenal glands or indirectly via the hypothalamus–pituitary axis (Wang, Lee, Lin, & Chang, 1998). A study reported that hot water extract has a mild beneficial effect on sexual function in castrated rats (Ji et al., 2009).

A clinical study reported that CS supplement to 22 males, showed increased sperm count (33%) and decreased incidence of sperm malformations (29%) (Guo, 1986). In another study involving both men and women of 189 patients with decreased libido and desire showed improvement of symptoms and desire of 66% upon treatment with CS (Wan, Guo, & Deng, 1988). Further, after CS supplement caused prevention and improvement of adrenal glands and thymus hormones, and infertile sperm count improved by 300% (Huang et al., 1987), improvement of libido and desire at 86% in woman (Dong & Yao, 2007).

6.11. Anti-fatigue and improves stamina

Many studies were conducted to prove that CS reduces fatigue and boosts stamina for athletes. Hot water (HW) fraction of mycelium of CS mainly contains carbohydrate (78.9%) was orally administered to mice to determine the swimming endurance capacity using an adjustable current swimming pool. CS was found to prolong swimming time (75–90 min) of test groups as compared to the control indicating HWs extract has effect on recovery from exhaustion with lessening of fatigue (Koh et al., 2003). And in similar studies, mice demonstrated their improved swimming capabilities after 6 weeks of CS supplementation compared with a control group (Xiao et al., 1999). In an in vivo pharmacology study, effects of CordyMax Cs-4, a mycelial fermentation product of CS, on energy metabolism was evaluated. In mice administered with CS-4, they found an increased level of β adenosine triphosphate (ATP) in liver suggesting a higher hepatic bioenergy status, suggesting clinical effectiveness of CordyMax in alleviating fatigue and improving physical endurance, especially in elderly subjects (Dai, 2001).

Unbelievable performance by Chinese women athletes at Chinese National Games in Beijing in September 1993 astounded the world of international track and field. This has attracted international attention to caterpillar fungus (Steinkraus, 1994).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104994/

Maca (Lepidium meyenii) is an Andean plant that belongs to the brassica (mustard) family. Maca has been used for centuries in the Andes to enhance fertility in humans and animals [12,13]. Preparations from the maca root have been reported to improve sexual function in healthy populations [13]. Although maca is a plant extract and not a drug, it is one of the most commonly cited "natural drugs" on the Internet for the improvement of sexual desire. The hypothesis that maca may be effective in improving sexual function is supported by several lines of evidence. Animal experiments suggest that maca has spermatogenic and fertility-enhancing activities, which are likely due to the phytosterols or phytoestrogens present in the maca [14]. Several in vivo studies have shown that maca may improve sexual behaviour and enhance androgen-like effects in rats [15,16]. Recent clinical trials have also suggested significant effects of maca for increasing sperm count and mobility and improving sexual function in humans [17,18]. The potential bioactive ingredients in maca include macaridine, macamides, macaene, gluosinolates, maca alkaloid, and maca nutrients [14]. 

  1. Tharakan B, Manyam BV. Botanical therapies in sexual dysfunction. Phytotherapy Research. 2005;19(6):457–463. doi: 10.1002/ptr.1634. [PubMed] [CrossRef] [Google Scholar]
  2. Hudson T. Maca: new insights on an ancient plant. Integrative Medicine: A Clinician's Journal. 2008;7(6):54–57. [Google Scholar]
  3. Wang Y, Wang Y, McNeil B, Harvey LM. Maca: an Andean crop with multi-pharmacological functions. Food Res Intern. 2007;40:783–792. doi: 10.1016/j.foodres.2007.02.005. [CrossRef] [Google Scholar]
  4. Gonzales GF, Ruiz A, Gonzales C, Villegas L, Cordova A. Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats. Asian J Androl. 2001;3(3):231–233. [PubMed] [Google Scholar]
  5. Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY. Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology. 2000;55(4):598–602. doi: 10.1016/S0090-4295(99)00549-X. [PubMed] [CrossRef] [Google Scholar]

An improvement in sexual desire was observed with Maca since 8 weeks of treatment. Serum testosterone and oestradiol levels were not different in men treated with Maca and in those treated with placebo (P:NS). Logistic regression analysis showed that Maca has an independent effect on sexual desire at 8 and 12 weeks of treatment, and this effect is not because of changes in either Hamilton scores for depression or anxiety or serum testosterone and oestradiol levels. In conclusion, treatment with Maca improved sexual desire.

https://pubmed.ncbi.nlm.nih.gov/12472620/

Maca

Maca is a vegetable derived from the Lepidium meyenii plant and has been historically used as both a nutritional supplement and fertility enhancer[33]. Studies on the usage of maca for sexual enhancement are limited, and to date there is no clearly understood mechanism of action. When studied in animal models, a lipid extract derived from the Lepidium meyenii plant demonstrated increased sexual behavior in male mice and rats as measured by the number of complete intromissions over a 3-hour time period[47]. No specific studies on maca’s effects on ED in animals have been reported in the literature.

Although there is still limited data on maca’s use in human trials, Shin et al. conducted a systematic review of the literature to identify studies evaluating maca’s effects on humans[48]. Four RCTs successfully met the inclusion criteria, of which three discussed effects of maca on healthy men, postmenopausal women, and athletes[49–51]. One trial discussed the effect of 2400 mg of maca for 12 weeks on men with erectile dysfunction using the IIEF-5 score and reported that patients treated with both maca and a placebo observed an increase in erectile function at the end of the treatment period. However, patients taking maca reported a greater improvement in IIEF scores than patients treated with the placebo (1.6 +/− 1.1 versus 0.5 +/− 0.6 points, p < 0.001)[52]. Despite these findings, Shin et al. concluded that there is not enough evidence to establish a relationship between the usage of maca and improved sexual function due to the limited number of trials, small sample size, and varying supplementation regimens[48].

Only one study has reported that maca improves erectile function in men with ED[52]. There is limited additional literature to suggest maca is an effective supplement in ED treatment. Furthermore, no studies have been conducted on the adverse effects of maca and its side effect profile remains unknown; as such further research is required to determine its role in the management of ED[48].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340557/

 

Consumption of spray-dried extracts of red and black maca resulted in improvement in mood, energy, and health status, and reduced CMS score. Fatty acids and macamides were higher in spray-dried extracts of black maca than in red maca. GABA predominated in spray-dried extracts of red maca. Effects on mood, energy, and CMS score were better with red maca. Black maca and, in smaller proportions, red maca reduced hemoglobin levels only in highlanders with abnormally high hemoglobin levels; neither variety of maca reduced hemoglobin levels in lowlanders. Black maca reduced blood glucose levels.

lthough red maca increased sexual desire more than black maca, the effect seems to be modest since it represented only 50% of the subjects. Moreover, a placebo effect was observed particularly at HA. In a previous study using gelatinized maca in men at LA, sexual desire increased only in 42% and after eight weeks of treatment [16]. Maca dry extract supplementation was also useful to improve subjective perception of general and sexual well-being in adult men with mild erectile dysfunction [17]. Another study using maca flour at a dose of 3.3 g/day for six weeks was unable to show an increase in sexual desire in post-menopausal women [15]. Stone et al. [14] showed an increase in sexual desire at week 4 using an extract of unidentified maca. Although extract of maca, particularly the red phenotype, seems to be better than flour or gelatinized maca, the results are still modest.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039502/

Results. 45 of 57 consented females were randomized, and 42 (30 premenopausal and 12 postmenopausal women) were eligible for a modified intent-to-treat analysis based on having had at least one postmedication visit. Remission rates by the end of treatment were higher for the maca than the placebo group, based on attainment of an ASEX total score ≤ 10 (9.5% for maca versus 4.8% for placebo), attaining an MGH-SFQ score ≤ 12 (30.0% for maca versus 20.0% for placebo) and reaching an MGH-SFQ score ≤ 8 (9.5% for maca versus 5.0% for placebo). Higher remission rates for the maca versus placebo group were associated with postmenopausal status. Maca was well tolerated. Conclusion. Maca root may alleviate SSRI-induced sexual dysfunction in postmenopausal women. This trial is registered with NCT00568126.

In one of the few published studies of maca in women, early postmenopausal women treated with maca were more likely than those who received placebo to show significant decreases in follicle stimulating hormone (FSH) and significant increases in luteinizing hormone (LH) production [24]. In addition, several studies do at least suggest that maca improves menopausal symptoms [20, 24]. For the postmenopausal female population, while the paucity of data precludes any reasonable inference of effectiveness, let alone mechanism of the effect [25], it is quite possible that maca ameliorates postmenopausal symptoms through an androgenic mechanism. Recently, an interesting case report in the British Medical Journal detailed the case of testosterone assay interference by maca, suggesting that maca contains an as of yet unspecified compound with a similar moiety to the human testosterone molecule and that it may be exerting its androgenic effects through actions at the testosterone receptor on target organs without affecting the level of testosterone or gonadotrophins [26]. This may explain why studies in men demonstrate a lack of effect of maca on serum hormone levels [19, 22, 27, 28].

In a prior trial we recently demonstrated that maca treatment may yield improvement in libido in women with AISD [21]. At a dose of 3 grams per day women described greater sexual activity and more enjoyable sexual experiences. In view of the encouraging preliminary findings, we sought to validate the results of our first open-label dose-finding study by conducting a double-blind placebo-controlled trial of maca root in the treatment of AISD in women. An additional aim of the study was to document the safety and tolerability of maca root. Further we intend to explore the hypothesis that the salutary effects of maca on sexual dysfunction derive from an androgenic response.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411442/

Horny Goat Weed

Epimedium extract (Horny Goat Weed) (11), (Figure 9): the Chinese refer to this herb as ‘yin yang huo’, which has been loosely translated as ‘licentious goat plant’; hence, its common name is well known as ‘horny goat weed’ by many Western cultures. Scientifically, studies have shown that Epimedium may restore low levels of both testosterone and thyroid hormone, bringing low levels back to their normal levels (5), which may account for some of its benefits in improving sexual libido. Other benefits to Epimedium involve increased muscle mass. Used for fatigue and aging, And vasodilatation effect; thus, most frequently used in treatment of sexual dysfunction in Traditional Chinese Medicine (12). The active substance from horny goat weed was reported by Xin Zhong Cheng at Beijing Medical University as Icarin—acts by increasing sexual activities and ICP levels in castrated rats after long term oral administration. It has no effects on serum testosterone level in castrated rats after long term oral administration. Instead Icariin increases nNOS and iNOS mRNA and protein expression in the corpus cavernosum after long term oral administration and hence may have long term efficacy on erectile dysfunction after oral administration.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422695/

Icariin has a wide range of effects on reproductive functions in male rats. We, for the first time, report that an appropriate dose of icariin can increase testosterone production by regulating the expressions of genes such as StAR and PBR; icariin can also affect spermatogenesis by regulating FSHR and claudin-11 mRNA expression. However, an excessive dose of icariin may cause adverse effects such as tissue and organ oxidative damage, consequently damaging reproductive functions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271987/

Horny Goat Weed

Horny goat weed (HGW) extract is derived from the Epimedium grandiflorumplant. Named after its aphrodisiac effects on goats who ate the leaves of E. grandiflorum, HGW is commonly used in many men’s health supplements[33]. The bioactive ingredient in HGW is icariin, which has historically been used as an aphrodisiac and herbal treatment for ED in Chinese men[34]. Icariin has PDE5 inhibitor activity in vitro and may mimic some properties of testosterone[7]. Studies suggest icariin also enhances smooth muscle proliferation and has neurotrophic effects that may be beneficial for treatment-refractory ED in the context of hypertension or diabetes-induced endothelial cell damage[35–37].

Shindel et al. examined the effect of varying dosages of icariin (1 mg/kg, 5 mg/kg, and 10 mg/kg) on intracavernosal pressure (ICP) in rats with surgical injury of the cavernous nerve over the course of 4 weeks[35]. Icariin increased intracavernosal pressure, and rats in the 1 mg/kg and 10 mg/kg groups had significantly increased ICP/MAP ratios (p < 0.05). Rats treated with 5 mg/kg icariin had higher mean ICP/MAP ratios, but the difference was not statistically significant (confidence interval: −0.8187–0.0313). Icariin also increased penile expression of neuronal NO synthase on Western blots in all treatment groups as compared to rats that did not receive icariin[35]. Though these preliminary studies are promising, further studies on the use of HGW in both animal and human models are scarce. Additionally, no definitive studies have characterized the utility or toxicity of icariin in humans. With a lack of both evidence-based efficacy and an understanding of its side effect profile, further studies on HGW should be performed to assess its application in treatment of ED.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340557/

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551978/

ICA may have neurotrophic effects in addition to known phosphodiesterase type 5 inhibiting effects. Epimedium species (aka horny goat weed) have been utilized for the treatment of erectile dysfunction in Traditional Chinese Medicine for many years. Icariin (ICA) is the active moiety of Epimedium species.

https://pubmed.ncbi.nlm.nih.gov/20141584/