Scientific Research for Vitality-Energy

Vitality-Energy

Vitality-Energy is an energy-boosting combo of potent mushrooms and Gac fruit extract that support physical performance, improve energy reservoirs, and assists vital physiological functions. It significantly helps exhaustion, muscles recovery, early fatigue and promotes optimal life quality and vitality. Moreover, regular consumption of Vitality-Energy by FUNGAC Essentials Inc. helps daily life activities, relieves mental fatigue, and enhances work productivity. Additionally, it protects cellular integrity, promotes mitochondrial function, and increases ATP production, which helps physical endurance and delays muscle fatigue. It is important to know that qualified experts processed the Vitality-Energy formulation in a well-certified facility following GMP guidelines. The end product is highly beneficial for both men and women. Additionally, the final formulation is packed with Black Pepper Extract for maximum absorption and protection in the gastrointestinal tract.

Features of Vitality-Energy by FUNGAC Essentials Inc. 

  • USDA Certified Organic Ingredients
  • No-Risk of Side Effects
  • Free from Synthetic Chemicals
  • Support Physical Performance
  • Improve Vital Functions
  • Promote Energy Production
  • Help Vitality and Longevity
  • Aid Muscles Recovery Process
  • Non-GMO and Gluten Free
  • Premium Adaptogens at Cheap Price

How does Vitality-Energy formula Work?

The potent mushrooms combined with GAC fruit extract modulate metabolism, preserve cellular integrity, improve mitochondrial function and increase energy production that supports daily activities and enhance physical performance. Moreover, it helps the body in optimal consumption of oxygen, clearance of lactic acid, and muscle recovery processes that further aid performance, endurance, and stamina. Additionally, Vitality-Energy helps ventilator threshold and glucose reuptake for energy production that maximizes physical endurance. 

Health Benefits of Vitality-Energy

Support Physical Performance

The Adaptogenic mushrooms in the Vitality-Energy formulation increase mitochondrial activity, enhance energy production and support physical performance for maximum productivity. Moreover, it improves blood flow to vital organs and boosts oxygen utilization that potentiates aerobic performance. Additionally, Vitality-Energy delays muscle exhaustion, aids the recovery process and enhances physical endurance and stamina.

Improve Vitality and Longevity

Regular consumption of Vitality-Energy removes reactive species, protects cellular integrity, and prevents vital organs damage. Further, it assists blood flow to vital organs and promotes optimal functioning, which improves vitality and helps longevity. Also, the Vitality-Energy formula by FUNGAC Essentials Inc. decreases lactic acid production, delays fatigue, and increases lactate clearance that helps muscles function and extends working capability. 

Note, please read the Vitality-Energy label for suggested dose and precautionary measures.

 

 

References (Medical Research Studies)

 

Copied Research Data

Cordycepin and Anti-Osteoporosis Effect

Osteoporosis is a condition of low bone mineral density (BMD) and loss of the structural and bio-mechanical properties of bones. It increases the risk of fracture, as bones become more porous and fragile. Osteoporosis mainly occurs in aged people, specifically in post-menopausal women and patients who had long-term treatment of steroid therapy. Anti-osteoporotic effect of cordycepin was studied in ovariectomized osteopenic rats, it has been found that cordycepin was able to counteract the loss of bone in the experimental model. The mechanistic approach used in this study showed the decline in activity of tartrate-resistant acid phosphatase and alkaline phosphatase enzymes both in vitro and in vivo. Moreover, the results showed that oral intake of cordycepin could increase the level of osteocalcin (OC), a marker of bone formation, and decrease C-terminal cross-linked telopeptide of type I collagen (CTX) level, a marker of bone resorption, as well as restore oxidative stress levels in ovariectomized rats [104]. These results suggest that cordycepin can be a valuable bioactive compound for the treatment of osteoporosis and is able to prevent bone loss caused by estrogen deficiency. Cordycepin was also reported to inhibit RANKL-induced osteoclast differentiation (RANKL), receptor activator of nuclear factor kappa-Β ligand, and down-regulate the mRNA expressions of osteoclastogenesis-related genes such as, matrix metalloproteinase (MMP)-9, cathepsin K, tartrate-resistant alkaline phosphatase (TRAP) and nuclear factor of activated T-cells, cytoplasmic 1 [105].

6.6. Cordycepin and Anti-Arthritic Effect

Arthritis, an autoimmune disease affecting bone joints, is mainly characterized by joint stiffness as well as joint pain, among other symptoms such as swelling, warmth, redness, and reduction in joint motility. There is no known specific effective treatment for arthritis, although many drugs such as glucocorticosteroids, non-steroidal anti-inflammatory drugs, and other biological agents are used to improve the symptoms, such as pain, fatigue, and disability. Long-term usage of these drugs decreases their effectiveness and increases side effects. Recently, studies were conducted looking for effective anti-arthritic drugs with increased therapeutic effects and fewer side effects. Traditional herbal medicine, which is shown to be more effective, safer, and economical, has attracted more attention in the area of arthritis treatment. Moreover, cordycepin has been found to modulate glycosaminoglycan (GAG) release by suppressing stimulation of IL-1β. In addition, levels of proteases that have been reported in cartilage matrix degradation, such as MMP-13, cathepsin K, MMP-1, cathepsin S, ADAMTS-5 and ADAMTS-4, were decreased by cordycepin in a dose-dependent manner. Chondroprotective effect of cordycepin by preventing cartilage denegation as well as interfering inflammatory response in osteoarthritis pathogenesis has also been reported [106]. Cordycepin has been reported to reduce excessive inflammatory cell infiltration via down-regulation of macrophages, interferon gamma-induced protein 10 (IP-10) and Mig expressions through terminating protein coding gene (STAT1) phosphorylation [107]. There are some reports suggesting that inflammation of T-cell infiltration could be inhibited by using a cordycepin concentration of 10 mg/kg. According to that report, cordycepin can regulate the T-cell receptor, a protein complex found on the surface of T-cells, that signals to suppress excessive T-cell activation in inflammation [108]. Therefore, based upon these reports, it can be concluded that cordycepin has therapeutic potential in both anti-catabolic and anti-inflammatory actions against arthritic diseases [107,108].

6.7. Cordycepin and Antioxidant Effect

Antioxidants are compounds that can prevent or slow down oxidation reactions producing free radicals, that ultimately cause cell damage in organisms. Oxidative stress, which is related with an increased formation of oxidizing species or a significant reduction of natural antioxidant levels, is involved in different human diseases (cellular necrosis, cardiovascular disease, cancer, neurological disorder, ageing) [109]. Non-toxic antioxidants from natural sources, particularly medicinal plants, are known to prevent oxidative damage due to their richness in polyphenolics and bioactive compounds [110,111,112,113,114]. The antioxidant activity of Cordyceps has been reported by various authors [115,116]. Cordycepin has been reported to significantly increase the levels of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase activities in 6-OHDA-treated cells. Moreover, the results showed that cordycepin prevents 6-OHDA-induced neurotoxicity in adrenal pheochromocytoma cells (PC12 cells) via its potent antioxidant action [117]. In addition, cordycepin containing protein-bound polysaccharide causes a reduction in lipid peroxidation as well as an increase in the activity of antioxidant enzymes in the liver like catalase and superoxide dismutase [118]. Other authors have suggested the potential of cordycepin in reducing lipid peroxidation in mouse liver [119]. Therefore, per these reports, cordycepin could be considered as a potential antioxidant. A few studies have even suggested that the antioxidant potential of Cordyceps is close to that of ascorbic acid [120].

6.9. Cordycepin and Other Diseases

Hyperuricemia is a long-time purine metabolic disorder recognized as a result of excessive serum uric acid status in blood and associated with gout, renal sicknesses, hypertension, hyperlipidemia, and atherosclerosis [96,131]. C. militaris has been reported for its anti-hyperuricemic effect in hyperuricemic mice at different doses, reaching the levels of normal mice [132]. In another study, Yong et al. [133] also reported cordycepin’s potential as an anti-hyperuricemic in hyperuricemic mice. Infertility can be described as a disease condition where females are not able to become pregnant despite having frequent, unprotected sex for at least a year for most couples. According to the reports, cordycepin has been proved potent in increasing both the sperm quality and quantity. C. militaris supplementation has been stated to bring about an increase of serum cordycepin concentration, which concurrently enhances testosterone and estradiol-17 levels, ultimately increasing the percentage of motile sperm cells [134]. In addition to this cordycepin is also reported to increase semen production as well as sperm quality in boars [66]. The effect of cordycepin on testosterone levels in male rats was reported. It was found that the concentration of testosterone in the serum of the rats was significantly increased by C. militaris. Therefore, fruiting bodies of C. militaris grown on the drone bee medium could act as an integrative medicine for the treatment of reproductive problems caused by insufficient testosterone levels in human males [135]. On the other hand, chronic kidney disease (CKD) is a disease condition where the condition of the kidneys deteriorates steadily and has been related with both non-communicable diseases, e.g., diabetes and hypertension, and infectious diseases like hepatitis B, malaria, and HIV [136]. Clinical research exploring the possible cordycepin application has confirmed the beneficial effects in decreasing the progression of end-stage kidney disease in CKD patients [137]. Moreover, other pharmaceutical applications of cordycepin are also recommended, such as increasing creatinine clearance, serum albumin and hemoglobin, lowering serum creatinine levels as well as improving lipid metabolism [137,138,139,140].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356751/

Anti-fatigue and improves stamina

Many studies were conducted to prove that CS reduces fatigue and boosts stamina for athletes. Hot water (HW) fraction of mycelium of CS mainly contains carbohydrate (78.9%) was orally administered to mice to determine the swimming endurance capacity using an adjustable current swimming pool. CS was found to prolong swimming time (75–90 min) of test groups as compared to the control indicating HWs extract has effect on recovery from exhaustion with lessening of fatigue (Koh et al., 2003). And in similar studies, mice demonstrated their improved swimming capabilities after 6 weeks of CS supplementation compared with a control group (Xiao et al., 1999). In an in vivo pharmacology study, effects of CordyMax Cs-4, a mycelial fermentation product of CS, on energy metabolism was evaluated. In mice administered with CS-4, they found an increased level of β adenosine triphosphate (ATP) in liver suggesting a higher hepatic bioenergy status, suggesting clinical effectiveness of CordyMax in alleviating fatigue and improving physical endurance, especially in elderly subjects (Dai, 2001).

Unbelievable performance by Chinese women athletes at Chinese National Games in Beijing in September 1993 astounded the world of international track and field. This has attracted international attention to caterpillar fungus (Steinkraus, 1994).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104994/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/

Recent literature further confirms that Cordyceps enhances cellular energy in the form of ATP (adenosine tri-phosphate). Upon hydrolysis of phosphates from ATP, lots of energy is released which is further used by the cell (Dai et al. 2001; Siu et al. 2004).

Described as a natural exercise mimetic (Kumar et al., 2011), cordyceps is thought to improve performance by increasing blood flow, enhancing oxygen utilization, and acting as an antioxidant (Ko & Leung, 2007; Zhu, et al., 1998a, 1998b). Related to these benefits, a majority of the effects of cordyceps sinensis supplementation have been seen in aerobic performance, showing improvements in maximal oxygen consumption (VO2max) and ventilatory threshold (VT) (Chen et al., 2010; Nicodemus, Hagan, Zhu, & Baker, 2001; Yi, Xi-zhen, & Jia-shi, 2004). Indirectly, there may also be potential effects of cordyceps supplementation on high intensity performance. Enhanced oxygen utilization and blood flow, especially to the liver and non-exercising skeletal muscle, may enhance lactate clearance. This may allow athletes to maintain a higher intensity of exercise, while the reduction of oxidative stress from high intensity exercise may delay fatigue (Adams & Welch, 1980; Brooks, 1985; Mizuno et al., 2008; Rowell et al., 1966). When combined with three weeks of high intensity interval training, a pre-workout blend containing cordyceps sinensis had positive effects on critical velocity, an aerobic performance measure (Smith, Fukuda, Kendall, & Stout, 2010). Despite potential benefits, a number of studies have found no benefits of cordyceps supplementation on aerobic and anaerobic performance (Colson et al., 2005; Earnest et al., 2004; Parcell, Smith, Schulthies, Myrer, & Fellingham, 2004). To date, research on the ergogenic effects of cordyceps is limited and inconclusive as to its benefits to exercise.

Available studies utilizing cordyceps vary considerably in dosing and supplementation duration. Higher doses of cordyceps sinensis (3 g·d−1) have resulted in significant benefits on VO2max and VT (Nicodemus, et al., 2001; Yi, et al., 2004); doses of 4.5 g·d−1 also significantly augmented VO2max, VT, in addition to delaying lactate production and enhancing metabolic efficiency (Nicodemus, et al., 2001). Lower doses (1 g·d−1) have been less likely to result in significant effects, except for situations of prolonged supplementation (12 weeks) (Chen, et al., 2010; Colson, et al., 2005; Earnest, et al., 2004). Based on available data, higher dosages (3 – 4.5 g·d−1) in combination with longer interventions (5 – 6 weeks) seem to produce the best results, but the acute effects of a higher dosage are currently unclear. Therefore, the primary purpose of this study was to determine the acute (1-week) effects of a cordyceps militaris (4 g·d−1) containing mushroom blend on aerobic performance, including oxygen kinetics (VO2max, VT), and time to exhaustion (TTE).

After three weeks of supplementation in the current study, there were significant increases in VO2max (10.9%) compared to a control and a significant increase in VT (41.2%) and TTE (8.2%) pre to post. Improvements in VO2max and VT are consistent with a similar study in male endurance athletes, where VO2max and VT increased after cordyceps sinensis supplementation at a similar dosage (4.5 g·d−1) (Nicodemus, et al., 2001). In the same study, respiratory exchange ratio was lower throughout submaximal exercise with supplementation, indicating cordyceps sinensis may potentially enhance fat oxidation. In rats, cordyceps sinensis upregulated skeletal muscle metabolic regulators, promoted angiogenesis, and increased glucose uptake, improving endurance capacity and delaying fatigue (Kumar, et al., 2011). Mitochondrial biogenesis was increased in the rat model, which may have a subsequent influence on fatty acid oxidation and glycogen turnover, increasing ATP availability and improving performance. Cordyceps has also been shown to act as an antioxidant, potentially reducing exercise induced oxidative stress (Ko & Leung, 2007), and improving the ability to withstand high intensity exercise. While a cordyceps militaris containing mushroom blend did improve the ability to withstand high intensity exercise to a moderate degree, it should be noted that the MR group had a lower, but not significantly different (p>0.05), baseline VT (1.7 l·min−1) compared to PL (2.4 l·min−1) and post-test values between groups were identical (2.4 min−1). In the current study, evaluation of three weeks of a cordyceps militaris containing mushroom blend was an exploratory aim. Despite the limited sample size, based on the duration and amount of cordyceps reported from previous studies, and with respect to the present study, an ergogenic response is likely dose dependent with 3 - 4 g·d−1, with a more chronic consumption resulting in a greater ergogenic benefits. These results should be further verified in a larger sample size.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/

In conclusion, we have successfully confirmed that Cordyceps militaris induces fatigue recovery via activating AMPK and AKT/mTOR pathways and regulating serum hormone level. Our data provides experimental evidence in supporting clinical use of Cordyceps militaris as an effective agent against fatigue. Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5′-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553310/

 

Eleutherococcus senticosus

Positive Findings Of the studies reviewed, three suggest that ES offers an ergogenic advantage during endurance exercise (1, 21, 26). Each of these studies, however, suffers from several methodological weaknesses, making the generalization of the results questionable. Although these studies were published in peer-reviewed journals, these journals were nonexercise/nutrition science journals. These studies, as well as those reporting negative findings, are summarized in Table 1. Asano et al. (1) were the first to report that ES supplementation improves EP compared with a placebo. First, subjects completed three cycling tests to exhaustion (step-incremented VO2max tests) over three consecutive days without any form of supplementation. Then, subjects were supplemented with the placebo for 8 d after which they underwent another cycling test. After the placebo trial, subjects were supplemented for 8 d with ES (300 mg/d) and then performed a final cycling test. The treatments were administered in a single-blind fashion and subjects served as their own control. Compared with the placebo, ES increased cycling time to exhaustion and total work capacity by 10 and 15%, respectively. Despite these improvements, there were no differences between treatments for VO2max and oxygen pulse. Compared with the pre-supplementation trials, however, ES improved VO2max and oxygen pulse as well as cycling time to exhaustion (16%) and total work capacity (23%). Asano et al. (1) speculated that the efficacy of ES could be caused by the fact that it increases the number of mitochondria in muscle cells. Their findings, however, should be interpreted with caution, because the experimental design contains important methodological errors, which seriously threaten the internal validity of the observed results (10). First, only a single-blind protocol was used. Second, the researchers did not employ a crossover design. Instead, they had the subjects perform three pre-supplementation trials first, then the placebo and, finally, the ES trial. Thus, an order/training effect, and not the effect of ES per se, could be responsible for the observed results. Wu et al. (26) evaluated the effects of ES on cardiorespiratory fitness (CF) and FAM during a step-incremented submaximal cycling exercise. Eight subjects were given the placebo for 3 d, after which they underwent a first test. Following this trial, they were supplemented with 800 mg/d of ES for 14 d and then underwent a second test. The submaximal cycling test started at an initial load of 60 W for 3 min, after which it was increased every 3 min by 30 W, up to 210 W. Compared with the placebo, ES decreased HR. ES also significantly reduced LA by 33%, increased the load and VO2 at AT (defined as 4 mmol/L) by 12 and 7%, respectively, and enhanced FAM by 43%. Fifteen minutes after the test, ES significantly decreased LA and HR by 34 and 13%, respectively. The Wu et al. study (26) possesses methodological flaws similar to those of Asano et al. (1), thereby making its results hard to interpret and difficult to generalize to the athletic population. Researchers from Poland investigated the effects of ES on CF and FAM during a VO2max test (21). A pre/post comparison design, with no placebo, was used. Thirty-one healthy subjects were tested for VO2max and, upon exhaustion, measures of VO2 , VCO2 , HR, respiratory exchange ratio (RER), and minute ventilation (VE) were taken. For a period of 30 d between trials, subjects were supplemented with 25 drops of ES three times daily. Compared with the pre-supplementation trial, ES significantly improved VO2max and maximal VE. There were, however, no differences between trials for the remaining variables. Unfortunately, because of the failure to include a placebo, the interpretation of the results is problematic.

 

Asano, K., T. Takahashi, M. Miyashita, A. Matsuzaka, S. Muramatsu, and M. Kuboyama et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med. 3:175-177, 1986.

Szolomicki, S., L. Samochowiec, J. Wojcicki, and M. Drozdzik. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother. Res. 14:30-35, 2000.

Wu, Y.N., X.Q. Wang, Y.F. Zhao, J.Z. Wang, H.J. Chen, and H.Z. Liu et al. Effect of Ciwujia (Radix acanthopanacis senticosus) preparation on human stamina. J. Hyg. Res. 25:57-61, 1996.

 

                                                                                                                                               

ubjects cycled at 75% VO2 peak until exhaustion. The examined physiological variables included endurance time, maximal heart rate during exhaustion exercise, VO2, rating of perceived exertion and respiratory exchange ratio. The biochemical variables including the plasma free fatty acid (FFA) and glucose were measured at rest, 15 min, 30 min and exhaustion. The major finding of this study was the VO2 peak of the subjects elevated 12% (P < 0.05), endurance time improved 23% (P < 0.05) and the highest heart rate increased 4% (P < 0.05) significantly. The second finding was at 30 min of 75% VO2 peak cycling, the production of plasma FFA was increased and the glucose level was decreased both significantly (P < 0.05) over 8-week ES supplementation. This is the first well-conducted study that shows that 8-week ES supplementation enhances endurance capacity, elevates cardiovascular functions and alters the metabolism for sparing glycogen in recreationally trained males.

https://pubmed.ncbi.nlm.nih.gov/21793317/

Recovery times after forced swimming were shorter in E. senticosus extract (500 and 1000 mg/kg)-treated mice than in vehicle-treated mice. The body and liver weight had no effect by the oral administration of E. senticosus extract, vitamin mixture and L-carnitine. Fatty acid β-oxidation activity in skeletal muscle was increased by E. senticosus extract (500 and 1000 mg/kg).

Conclusion:

  1. senticosus may enhance recovery from physical fatigue induced by forced swimming by accelerating energy changes through fatty acid β-oxidation in skeletal muscle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427804/

Eleutherococcus senticosus
Extract (2mg eleutherosides B and E equivalent to 2–4 g of herbal substance daily)/placebo for 2 months and 2 months of follow-up

R, PC, DB
2 parallel treatment groups 96 patients with chronic fatigue syndrome (49/47)
[21–65 years]

RVI measurement of fatigue reduced
Significant (p<0.05) improvement in RVI compared with control after 2 months treatment in the subgroups of patients with moderate fatigue at baseline (RVI value 8–12) and a history of fatigue <5 years. However, no significant difference was observed after 4 months treatment

Ib
  1. senticosusimproved mental performance in correction test; increased activity of the adrenal cortex, the activity of the sympathetic adrenomedullar system, the intensity of metabolic processes, and the intensity of red-ox processes. In stress conditions E. senticosusdecreased adrenal cortex activity and sympathetic nervous system; increased the tonus of the parasympathetic nervous system; moderately intensified excitation of the CNS and of energy metabolism; improved endurance to hypoxia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

Rhodiola Rosea

Adaptogen are “[most commonly] natural herbal products which are non-toxic in normal doses, produce a non-specific response, and have a normalizing physiologic influence” [5].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590898/

Previous studies have speculated that the ingestion of R. rosea can improve exercise performance via altered energy metabolism [16], activated by the synthesis or resynthesis of ATP in mitochondria and stimulated restorative energy processes after intense exercise [15].

https://pubmed.ncbi.nlm.nih.gov/15500079/